Glioblastoma Multiforme
GBM

Gliomas of the brain

• Most common primary supratentorial, intraaxial mass in adult
  
  
• Gliomas account for 35-45% of all intracranial tumors and glioblastoma multiforme accounts for more than half of them, astrocytomas about 20% and the remainder split between ependymomas, medulloblastoma, oligodendroglioma
  
  
• Glioblastoma multiforme has the worst prognosis of all gliomas
  
  
• Occurs more commonly in males between 65-75 years of age, especially in the frontal and temporal lobes
  
  
• Recognizing glioblastoma multiforme
  
  
  • As the most aggressive of tumors, glioblastoma multiforme frequently demonstrates necrosis within the tumor
    
    
• The tumor infiltrates the surrounding brain tissue, frequently crossing the white matter tracts of the corpus callosum to the opposite cerebral hemisphere producing a pattern called a butterfly glioma
  
  
• It tends to produce considerable vasogenic edema and mass effect and contrast enhances, at least in part

 

 

 
Glioblastoma Multiforme. There is a large contrast-enhancing mass in the right frontal region (red arrow) with a large amount of surrounding vasogenic edema (white arrows) and shift of the falx to the left from mass effect (black arrow).