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Hand-Foot Syndrome

• One of earliest changes of sickle-cell disease

• Occurs in small bones of hands and feet resulting from infarction

• Patients are usually less than two years of age

• First starts with painful swelling

• Usually in proximal phalanx or metacarpal

• Periosteal reaction and bone destruction are present

• Heals in a few months

• Indistinguishable by x-ray from osteomyelitis

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