· Most common benign tumor of esophagus
o Leiomyomas are also the most common benign tumor of the small bowel but are not common in the colon
· Usually asymptomatic
· May produce dysphagia or hematemesis if large
· Typically occurs in young males
· Found most often in distal third of esophagus
· Usually solitary, but may be multiple (3%)
· Imaging findings
o Smooth, sharply-marginated mass
o Well-defined, intramural (wall) mass lesion that typically intersects wall at 90 degree angle when viewed in profile
o As a wall lesion, it may narrow the lumen in one plane and widen it in the orthogonal view (a plane at 90 degrees to the original)
o May have coarse calcifications (only calcifying esophageal tumor)
o Rarely ulcerates

Leiomyoma of the esophagus. Large filling defect with sharply-marginated border is seen in distal esophagus.
Contrast seen within the lesion did represent an irregular ulcer in the mass. Leiomyomas are the most
common benign esophageal tumors.
For a larger photo of the same image, click here
· May demonstrate diffuse contrast-enhancement on CT
· DDx: Neurofibromas, hemangiomas and lipomas, all uncommon