-
Exogenous
accumulation of fat in the lung most often from mineral oil:
-
Older people who are
constipated, have a swallowing disorder 2° neurologic disease
-
In infants with
feeding difficulties
-
In the past, could
be from oily nose drops
-
Accumulation of fat
in the lung may also occur from endogenous sources such as fat embolism,
alveolar proteinosis lipid storage diseases
-
Animal fatty acids
(like fat embolus) produces hemorrhagic bronchopneumonia
-
Mineral oil
produces a giant cell foreign body reaction
-
Starts
as an alveolar infiltrate
-
Moves to
thicken interstitial septa, then
-
Into macrophages
enlarging lymphatics
-
Finally
produces a fibrosing reaction
